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We knew from previous research that being overweight and having excess body fat is a recognized risk factor for insulin resistance and type 2 diabetes, which complicate cancer therapy, says Thomas George, MD, a professor of medicine and interim director of the University of Florida Health Cancer Institute in Gainesville and one of the study authors

To minimize side effects and support weight loss, consider these guidelines: Avoid fatty, fried, high-sugar, and unhealthy fast foods Limit alcohol consumption Stay hydrated by drinking plenty of water What are the side effects of GLP-1/GIP

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Obesity and insulin resistance are also associated with increased inflammation